Fatigue Research Today is a free monthly online journal that collates and summarizes the latest research about Fatigue, including details on chronic fatigue syndrome, exhaustion, causes, diagnosis. | ||||||||
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A phase II study of methylphenidate for the treatment of fatigue.Hanna A, Sledge G, Mayer ML, Hanna N, Einhorn L, Monahan P, Daggy J, Bhatia S Division of Hematology/Oncology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA. amynasser@sbcglobal.net BACKGROUND: Cancer-related fatigue (CRF) is one of the most distressing symptoms patients experience and is seen well after the completion of treatment. Methylphenidate (Ritalin) use includes the treatment of opiate-induced somnolence, depression, and reduced cognition. This phase II study was performed to evaluate the effects of methylphenidate on CRF. PATIENTS AND METHODS: The criteria for the eligibility of patients included the following: a history of breast cancer, absence of disease for greater than 6 months but less than 5 years, a hemoglobin level of >12 g%, less than moderate depression on the Brief Zung Self-administered Depression Scale, and a score of > or =4 on the Brief Fatigue Inventory (BFI). Patients received methylphenidate, 5 mg, orally, twice daily, for 6 weeks, with a dose escalation on week 2 if the BFI score remained > or =4 and no significant toxicities were reported. A response was defined as a decrease in the BFI score of at least two points on weeks 4 and 6 as compared to baseline. RESULTS: Between May 2001 and May 2003, 37 patients were entered and treated. On weeks 4 and 6, 20 of 37 (54%) responded with a decreased BFI score greater than two points, averaging a decrease of 3.5. Although six patients (19%) withdrew due to adverse events, these were reported as grade 1. CONCLUSION: This study suggests that women with breast cancer who are suffering from moderate to severe fatigue may benefit from methylphenidate. Published 15 February 2006 in Support Care Cancer, 14(3): 210-5.
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